Laboratory of Comparative Cognition

Three-photon population imaging of subcortical brain regions

Frostig, H., Monasterio, A., Shvedov, N.R., Xia, H., Mishra, U., Britton, B., Giblin, J.T., Mertz, J., and Scott, B.B.

Nature Communications

• bioRxiv 2025

Psychedelics relax priors and reshape orbitofrontal dynamics

Delgado-Sallent, C., Ahmed, S.A., Khawaja-Lopez, A., Lee, B.S., Senne, R.A., Ramirez, S., and Scott, B.B.

Science Advances

• bioRxiv 2025

Computational mechanisms of perception in autism revealed using games inspired by rodent operant tasks

Chakravarty, S., Do, Q., Li, Y., Torres-Lacarra, V., Tager-Flusberg, H., McGuire, J.T., and Scott, B.B.

Science Advances · 2026

Covered byCTV News·The Brink·Dong-A Science

InterviewMedscriptum

Songbird connectome reveals tunneling of migratory neurons in the adult striatum

Shvedov, N.R., Castonguay, S.J., Rother, A., Schick, D., Kornfeld, J., and Scott, B.B.

Current Biology · 2026

• Video abstract
• Connectome

Covered byScientific American·The Brink·MDR Wissen

Regulation of decision threshold by the locus coeruleus

Xia, H., Maheu, M., Kane, G.A., and Scott, B.B.

Neuropsychopharmacology · 2026

A cross-species framework for investigating perceptual evidence accumulation

Chakravarty, S., Delgado-Sallent, C., Kane, G.A., Xia, H., Do, Q., Senne, R.A., and Scott, B.B.

eLife · 14:RP105116 · 2025

Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning

Affan, R.O., Bright, I.M., Pemberton, L., Cruzado, N.A., Scott, B.B., and Howard, M.W.

Journal of Neurophysiology · 2025

Rat movements reflect internal decision dynamics in an evidence accumulation task

Kane, G.A., Senne, R.A., and Scott, B.B.

Journal of Neurophysiology · 2024

Magnetic voluntary head-fixation in transgenic rats enables lifetime imaging of hippocampal neurons

Rich, P.D., Thiberge, Y.S., Scott, B.B., Guo, C., Tervo, D.G.R., Brody, C.D., Karpova, A.Y., Daw, N., and Tank, D.W.

Nature Communications · 2024

In vivo imaging in transgenic songbirds reveals superdiffusive neuron migration in the adult brain

Shvedov, N.R., Analoui, S., Dafalias, T., Bedell, B.L., Gardner, T.J., and Scott, B.B.

Cell Reports · 2024

CommentarySorrells, Cell Reports·Pytte, Trends in Neurosciences

High-resolution tracking of internal model formation using automated live-in training

Affan, R.O., and Scott, B.B.

Conference on Cognitive Computational Neuroscience · 2024

Assessing evidence accumulation and rule learning in humans with an online game

Do, Q., Li, Y., Kane, G.A., McGuire, J.T., and Scott, B.B.

Journal of Neurophysiology · 2023

Generalization in an evidence accumulation task

Do, Q., Hasselmo, M.E., and Scott, B.B.

Conference on Cognitive Computational Neuroscience · 2023

A miniature kinematic coupling device for head-restraint in mice

Kim, S.J., Slocum, A.H., and Scott, B.B.

Journal of Neuroscience Methods · 2022

GraFT: Graph filtered temporal dictionary learning for functional neural imaging

Charles, A.S., Cermak, N., Affan, R., Scott, B.B., Schiller, J., and Mishne, G.

IEEE Transactions on Image Processing · 2022

Imaging cortical dynamics in GCaMP transgenic rats with a head-mounted widefield macroscope

Scott, B.B., Thiberge, Y.S., Guo, C., Tervo, D.G.R., Brody, C.D., Karpova, A.Y., and Tank, D.W.

Neuron · 2018

• Video abstract

Covered bySimons Foundation·Nature Methods

Fronto-parietal cortical circuits encode accumulated evidence with a diversity of timescales

Scott, B.B., Constantinople, C.M., Akrami, A., Hanks, T., Brody, C.D., and Tank, D.W.

Neuron · 2017

• Video abstract

Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats

Scott, B.B., Constantinople, C.M., Erlich, J.C., Tank, D.W., and Brody, C.D.

eLife · 2015

Cellular resolution functional imaging in behaving rats using voluntary head restraint

Scott, B.B., Brody, C.D., and Tank, D.W.

Neuron · 2013

Covered byNature Methods

Wandering neuronal migration in the postnatal vertebrate forebrain

Scott, B.B., Gardner, T., Ji, N., Fee, M.S., and Lois, C.

Journal of Neuroscience · 2012

• Video

Transgenic songbirds offer an opportunity to develop a genetic model for vocal learning

Agate, R.J., Scott, B.B., Haripal, B., Lois, C., and Nottebohm, F.

PNAS · 2009

Developmental origin and identity of song system neurons born during vocal learning in songbirds

Scott, B.B., and Lois, C.

Journal of Comparative Neurology · 2007

Generation of transgenic birds with replication-deficient lentiviruses

Scott, B.B., and Lois, C.

Nature Protocols · 2006

Generation of tissue-specific transgenic birds

Scott, B.B., and Lois, C.

PNAS · 2005

Covered byMIT News·Boston Herald

Diurnal rhythms of choice: a state-dependent drift diffusion model uncovers time-dependent changes in rat decision making

Senne, R.A., Xia, H., Dubel, H.F., Do, Q., Kane, G., Fourie, J., Ramirez, S., Scott, B.B., and DePasquale, B.

bioRxiv · 2026

• bioRxiv

Guiding principles for shaping instructed behaviors in lab rodents

Maheu, M., and Scott, B.B.

PsyArXiv · 2025

• Preprint

A state-dependent drift diffusion model reveals mice actively explore a speed–accuracy continuum during decision-making

Senne, R.A., Delgado-Sallent, C., Ramirez, S., Scott, B.B., and DePasquale, B.

bioRxiv · 2025

• bioRxiv

CA1 engram cell dynamics before and after learning

Monasterio, A., Lienkaemper, C., Coello, S., Ocker, G.K., Scott, B.B., and Ramirez, S.

bioRxiv · 2024

• bioRxiv

Computational and systems neuroscience needs development

Scott, B.B.

The Transmitter · 2024

Advances in cellular resolution microscopy for brain imaging in rats

Kim, S.J., Affan, R.O., Frostig, H., Scott, B.B., and Alexander, A.S.

Neurophotonics · 2023

Everything, everywhere, all at once: functional specialization and distributed coding in the cerebral cortex

Affan, R.O., and Scott, B.B.

Neuron · 2022

Applications of avian transgenesis

Scott, B.B., Velho, T.A., Sim, S., and Lois, C.

ILAR Journal · 51(4), 353–361 · 2010

The wanderlust of newborn neocortical interneurons

Scott, B.B., and Sanjana, N.E.

Journal of Neuroscience · 29(22), 7114–7115 · 2009

Genetic strategy to prevent influenza virus infections in animals

Chen, J., Chen, S.C.Y., Stern, P., Scott, B.B., and Lois, C.

Journal of Infectious Diseases · 197(S1), S25–S28 · 2008

Production of transgenic birds using lentiviral vectors

Scott, B.B., and Lois, C.

Mammalian and Avian Transgenesis — New Approaches (Springer) · 221–230 · 2006