Ryan Senne (he/him/his)
PhD Student
Ryan began his research journey at Boston University under the mentorship of Dr. Steve Ramirez. His work in Dr. Ramirez's lab covered a range of topics, from exploring variations in whole brain protein expression under different environmental conditions to examining the role of astrocytes in fear memory and their interaction with memory engrams.
Currently, Ryan is expanding his research on astrocytes in the Scott Lab, focusing on their role in decision-making processes. His interest lies in understanding how astrocytes respond to neuromodulators like norepinephrine and how this influences dynamic state switching, enabling animals to adapt their decision-making strategies. In addition to his work in the Scott Lab, Ryan is co-mentored by Dr. Brian DePasquale, applying state-space models to study decision making and uncover latent neural dynamics.
Outside the lab, Ryan indulges in his passions for reading, crafting the perfect espresso with his Profitec Pro 600 machine, and baking sourdough bread. He is also a devoted cat-dad to Glia, his extremely sassy and spoiled calico cat.
Fun Facts
What is your favorite brain region and why?
The hippocampus mostly because its the first brain region I studied.
How did you get into science?
The very first thing I wanted to be was a physicist. For career day in the third grade, my dad borrowed a white smock from a local restaurant that sort of looked like a lab coat. We put pens and pencils in the front pocket and he gave me some of his safety glasses to distinguish me from any would-be doctors. That same year he got me a periodic table that I would stay up late at night trying to memorize (I can still remember the first 40 elements or so). On the family computer, I read about black holes, the big bang, Schrödinger’s cat—only to quickly relay this new information to family members and unwilling friends. The idea that everything could be reduced to atoms, which could be reduced to even smaller composite particles was such a profound idea to my young mind.
Unfortunately, I wasn’t destined to become the next Einstein. My love for the laws governing the cosmos was quickly overtaken by an affection for the chemical basis of life. I took three chemistry classes throughout high school and nearly majored in it here. But like physics, my interests in chemistry were eventually given up for today’s fascination: neuroscience.
When I look back on my life I think it becomes fairly clear why I eventually settled on neuroscience. Truth be told, physics, chemistry, or a more generic biology career would have satiated me just the same, save for one thing—my mom. Her struggle with a debilitating psychiatric condition has been the backdrop to much of my life. I think the early experience of watching a brain behaving in an atypical way never left me. Why should the most evolutionarily advanced piece of machinery be so prone to malfunction? Why such undeserved suffering? I became deeply uncomfortable with the idea that at any moment a person’s being could be stripped away by any myriad of conditions. What did that have to say about us as people?
Soren Kierkegaard wrote that “Life can only be understood backwards; but it must be lived forwards.” As a kid, I just wanted to understand. That’s all scientists ever want: to understand; to follow their questions till they reach some sort of catharsis in finally knowing a little bit more than they did the previous day. That’s what I am driven by. The brain, in my opinion, is one of the last true frontiers of science. My time spent in the lab feels like an expedition to the unknown. Nothing would make me happier in this life if I could plant my flag somewhere and know that I contributed: a dwarf atop the shoulders of giants. Science is for everyone, and while it’s easy to remember names, scientific discovery is driven by the same hunger for knowledge. That is what unites scientists and that is what makes science great. With a little hard work and a lot of luck, I hope to pave my way through the brain so I can make the world a little bit more knowing than before.
What is a day in the lab like for you?
Stare at my computer, forget to eat lunch, drink coffee instead of eating, look at my computer some more, profit.
What is a pet hypothesis you have?
Not really a hypothesis but moreso an objective fact: astrocytes are cooler than neurons. More seriously, I believe than in the future we will understand astrocytes as the "conductors" or "choreographers," of neuronal ensembles, dynamically interacting with the environment and allowing for greater information processing in the brain.
What is your favorite lab meeting food?
Nud Pob.
What's your go-to lunch spot?
Nud Pob.